Clodronic acid
CAS No. : 10596-23-3
(Synonyms: Clodronate)
| Size | Price | Stock |
|---|---|---|
| 1mg | $25 | In-stock |
| 5mg | $63 | In-stock |
| 10mg | $95 | In-stock |
| 25mg | $165 | In-stock |
| 50mg | $250 | In-stock |
| 100mg | $400 | In-stock |
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| Cat. No. : | HY-B0657 |
| M.Wt: | 244.89 |
| Formula: | CH4Cl2O6P2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Clodronic acid (Clodronate) is an orally active bisphosphonate. Clodronic acid inhibits osteoclast-mediated bone resorption. Clodronic acid reduces skeletal event risk in malignant bone disease, impairs malignant osteolysis, blocks bone matrix growth-factor release, induces apoptosis in osteoclasts and macrophages. Clodronic acid is effective in the maintenance or improvement of bone mineral density. Clodronic acid can be used for the research of multiple myeloma and postmenopausal osteoporosis[1][2][3]. In Vitro:Clodronic acid induces rapid apoptosis in osteoclasts by preventing translocation of ADP into mitochondria after being internalised via resorption. Consequently, ATP production is inhibited, leading to induction of apoptosis by means of release of cytochrome C into the cytoplasm[2]. In Vivo:Clodronic acid (6.25-25 mg/kg; p.o.; daily for 28 days) slightly decreases the hindpaw swelling at doses of 12.5 and 25 mg/kg[3].
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