m-PEG8-MS
CAS No. : 1059588-19-0
| Size | Price | Stock |
|---|---|---|
| 1g | $1130 | Get quote |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-117031 |
| M.Wt: | 462.55 |
| Formula: | C18H38O11S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
m-PEG8-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG8-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
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