Taraxasterol


CAS No. : 1059-14-9

1059-14-9
Price and Availability of CAS No. : 1059-14-9
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10mg $105 In-stock
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Cat. No. : HY-N1178
M.Wt: 426.72
Formula: C30H50O
Purity: >98 %
Solubility: DMSO : 1 mg/mL (ultrasonic;heat to 80°C);Ethanol : 4 mg/mL (ultrasonic)
Introduction of 1059-14-9 :

Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases[1][2][3]. In Vitro:Taraxasterol (5-18 μg/ml, 1 h) inhibits vascular inflammation in human umbilical vein endothelial cells by activating LXRα [3].
Taraxasterol (2.5-10 μg/ml, 24 h) exhibits anti-inflammatory effects on human osteoarthritic chondrocytes [5].
Taraxasterol (114.68 μM, 24 h) has anti-metastatic effects on prostate cancer cells [6].
Taraxasterol (5-18 μg/ml, 1 h) shows no cytotoxicity to human umbilical vein endothelial cells at concentrations below 15 μg/ml [3].
In Vivo:Taraxasterol (2.5, 5, and 10 mg/kg, i.p., 8 h) has a protective effect against acute lung injury in a lipopolysaccharide (HY-D1056)-induced acute lung injury mouse model[4].

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