Alteplase

Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters^[1][2][3][4].
The product size below only indicate the effective content of Alteplase. The ratio of Alteplase effective content : total content = 1:46-1:50. The actual ratio depends on the batch.) In Vitro:Alteplase ( 8.3 and 250 μg/mL, 12 h) shows a signifcant reduction in viability of human fetal retinal pigment epithelial (hfRPE cells)^[4].
Alteplase (8.3 and 250 μg/mL, 0-6 h) signifcantly decreases the transepithelial resistance in a time-dependent manner and induces cell death in hfRPE cells^[4].
Product Information
This product contains L-arginine, phosphoric acid, polysorbate 80, etc. as auxiliary materials. In Vivo:Alteplase (0.9-10 mg/kg, i.v., 20 to 40 minutes post ictus or 180 and 240 minutes post ictus) is beneficial when given early after stroke onset (<3 hours) and not beneficial when the administration is delayed (≥3 hours) in mice model of thromboembolic stroke^[3].