Tropisetron (Hydrochloride) (Standard)

Tropisetron (Hydrochloride) (Standard) is the analytical standard of Tropisetron (Hydrochloride). Tropisetron Hydrochloride (SDZ-ICS-930) is an effective neuroprotective agent that acts as a 5-HT3 receptor antagonist, a calmodulin inhibitor, and an α7-nAChRreceptor agonist, with an IC₅₀ of 70.1 nM for the 5-HT3 receptor. Tropisetron Hydrochloride has anti-inflammatory properties and immune-regulating functions, effectively alleviating symptoms associated with chemotherapy and post-surgery. Tropisetron Hydrochloride reduces Ab (HY-P4867)-induced hippocampal neuroinflammation^[1][2][3][4]. In Vitro:Tropisetron Hydrochloride (1-1000 nM, 1 h) has a neuroprotective effect against glutamate-induced excitotoxicity in pig retinal ganglion cells (RGCs), with an EC₅₀ of 62 nM^[1].
Tropisetron Hydrochloride (100 nM, 1 h) does not have a significant impact on the pAkt levels in RGCs, but it significantly lowers the p38 MAPK levels associated with excitotoxicity^[1].
Tropisetron Hydrochloride (1 nM-10 mM, 4 days) inhibits phosphatase activity in cerebellar granule neurons (CGNs)^[2].
Tropisetron Hydrochloride (1 nM-10 mM, 4 days) does not affect the viability of CGNs^[2].
Tropisetron Hydrochloride (10 nM-10 μM, 4 days) inhibits phosphatase activity in CGNs, increases CB1 expression, and reduces cAMP levels^[2]. In Vivo:Tropisetron Hydrochloride (5 mg/kg, intraperitoneal injection, once daily for 32 days) has immunomodulatory effects in mice with experimental autoimmune encephalomyelitis (EAE)^[3].
Tropisetron Hydrochloride (1 μg, ICV, single dose) reverses cognitive deficits in rats, providing protection against Ab (HY-P4867) induced neurotoxicity through both 5-HT3 receptor-dependent and independent pathways^[4].