Temafloxacin (hydrochloride)
CAS No. : 105784-61-0
(Synonyms: TMFX (hydrochloride); TA-167; A-62254)
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| Cat. No. : | HY-113595 |
| M.Wt: | 453.84 |
| Formula: | C21H19ClF3N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Temafloxacin (TMFX) hydrochloride is an orally active quinolone broad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections[1][2].
In Vitro: Temafloxacin hydrochloride (0-64 µg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of <0.004-0.5, 0.5-2 and 0.06-0.25 µg/mL for E. coli, P. aeruginosa, and S. aureus, respectively[1].
In Vivo: Temafloxacin hydrochloride (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis[1].
Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))[1].
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