PF-03715455
CAS No. : 1056164-52-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $125 | In-stock |
| 10mg | $200 | In-stock |
| 25mg | $400 | In-stock |
| 50mg | $680 | In-stock |
| 100mg | $1156 | Get quote |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-18862 |
| M.Wt: | 700.27 |
| Formula: | C35H34ClN7O3S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PF-03715455 is a potent inhaled p38 MAPK inhibitor. PF-03715455 shows some selectivity for p38α over p38β with respective IC50 values of 0.88 and 23 nM. PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM). PF-03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease)[1][2]. In Vitro: PF-03715455 is a moderate inhibitor of CYP1A2, CYP2C19, and CYP2D6 and a potent inhibitor of CYP’s 2C9 and CYP3A4[2]. In Vivo: PF-03715455 treatment shows that the Vss and T1/2 are 0.19 L/kg, 1 hour, respectively[2].
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