Tr-PEG2-OH
CAS No. : 105589-77-3
| Size | Price | Stock |
|---|---|---|
| 5g | $41 | In-stock |
| 25g | $125 | In-stock |
| 100g | $499 | In-stock |
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| Cat. No. : | HY-114995 |
| M.Wt: | 348.44 |
| Formula: | C23H24O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Tr-PEG2-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Tr-PEG2-OH is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
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