LY 345899
CAS No. : 10538-99-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $303 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $700 | In-stock |
| 100mg | $980 | In-stock |
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| Cat. No. : | HY-101943 |
| M.Wt: | 471.42 |
| Formula: | C20H21N7O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
LY 345899 is a Folate analog and is a methylene tetrahydrofolate dehydrogenase (MTHFD1; DC301) and MTHFD2 inbhibitor with IC50 values of 96 nM and 663 nM, respectively and a Ki of 18 nM for MTHFD1[1][2][3].
IC50 & Target:Ki: 18 nM (MTHFD1)[1]; IC50: 96 nM (MTHFD1) and 663 nM (MTHFD2)[3]
In Vitro:LY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria[4].
LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis[4].
In Vivo:LY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo[1].
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