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|---|---|---|
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| Cat. No. : | HY-118402 |
| M.Wt: | 438.35 |
| Formula: | C21H25Cl2N3O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
PD 119819 is a highly selective benzopyran-4-one brain dopamine autoreceptor agonist. PD 119819, a heterocyclic piperazine, inhibits spontaneous locomotor activity and brain dopamine synthesis[1][2]. IC50 & Target: dopamine autoreceptor[1] In Vivo: PD 119819 (5~80 mg/kg; nasogastric intubation) makes monkeys show marked increases in alanine aminotransferase levels and a moderate increase in ornithine carbamyltransferase levels at the initial sampling interval after doses of 5 mg/kg with peak levels occurring after doses of 20 or 60 mg/kg, while lower values is evident after doses of 80 mg/kg[1].
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