SBE13 (Hydrochloride)
CAS No. : 1052532-15-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $63 | In-stock |
| 10mg | $98 | In-stock |
| 25mg | $195 | In-stock |
| 50mg | $360 | In-stock |
| 100mg | $560 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
| We match the lowest price on market. | ||
We offer a substantial discount on larger orders, please inquire via [email protected]
or Fax: (86)21-58955996
Inquiry for price and availability only. Please place your order via our email or fax.
| Cat. No. : | HY-15158 |
| M.Wt: | 479.40 |
| Formula: | C24H28Cl2N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 5 mg/mL (ultrasonic) |
SBE13 Hydrochloride is a potent and selective Plk1 inhibitor, with an IC50 of 200 pM; SBE13 Hydrochloride poorly inhibits Plk2 (IC50>66?μM) or Plk3 (IC50=875?nM). IC50 & Target: IC50: 200 pM (Plk1), >66?μM (Plk2), 875?nM (Plk3)[1] In Vitro: SBE13 significantly reduce cell proliferation and induce apoptosis in HeLa cells, with an EC50 of 18?μM[1]. SBE13 (1-100 μM) shows no effect on Caspase 3/7 activity in NIH-3T3 cells. SBE13 (66 and 100 μM) does not change morphology after treatment of primary cells. SBE13 (10 and 100 μM) reduces pRb staining in primary cells, and this indicates a G0/G1 arrest[2]. SBE13 (66 and 100 μM) increases levels of cyclin B1, phospho histone H3, Wee1, Emi1 and securin, and results in cleavage of Cdc27 in HeLa cells. SBE13 (10 and 100 μM) also induces apoptosis of HeLa cells[3].
Lorem ipsum dolor sit amet, consectetur adipisicing elit. Autem earum hic iste maiores, nam neque rem suscipit. Adipisci consequatur error exercitationem fugit ipsam optio qui, quibusdam repellendus sed vero! Debitis.
Inquiry Information- Product Name:
- SBE13 (Hydrochloride)
- Cat. No.:
- HY-15158
- Quantity:
Your information is safe with us.