NSC145366 (monohydrochloride)
CAS No. : 1052515-37-3
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| Cat. No. : | HY-117192 |
| M.Wt: | 635.36 |
| Formula: | C37H63ClN2O4 |
| Purity: | >98 % |
| Solubility: |
NSC145366 monohydrochloride is a Hsp90 C-terminal inhibitor. NSC145366 monohydrochloride directly interacts with the C-terminus of Hsp90 and inhibits its chaperone activity. NSC145366 monohydrochloride strongly inhibits the growth of Saccharomyces cerevisiae cog7Δ and cog8Δ strains[1].
In Vitro:NSC145366 monohydrochloride (20-100 μM; 0-60 h) inhibits the growth of S. cerevisiae cog7Δ and cog8Δ strains, and induces selective sensitivity in ras2Δ strains[1].
NSC145366 monohydrochloride (500 μM; 2 h) directly binds to Hsp90 in MDA-MB-468 cell lysates[1].
NSC145366 monohydrochloride (10-40 μM; 60 min) dose-dependently inhibits the intrinsic chaperone activity of the recombinant Hsp90α C-terminal domain[1].
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