Osteogenic Growth Peptide (10-14)
CAS No. : 105250-85-9
(Synonyms: OGP(10-14); Historphin)
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| 10mg | $200 | In-stock |
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| Cat. No. : | HY-107024 |
| M.Wt: | 499.52 |
| Formula: | C24H29N5O7 |
| Purity: | >98 % |
| Solubility: | DMSO : 8.93 mg/mL (ultrasonic;warming;heat to 60°C) |
Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4].
In Vitro: Osteogenic Growth Peptide (10-14) (OGP(10-14)) induces proliferation and differentiation in fibroblast and osteoblast cell lines[3].
Osteogenic Growth Peptide (10-14) induces TPO-primed M07-e cells differentiation through RhoA/TGFβ1/SFKs signalling pathway. In particular Historphin acts as a Src inhibitor, showing the same effects of PP2[4].
In Vivo: Osteogenic Growth Peptide (10-14) (OGP(10-14)) increases bone formation and trabecular bone density and stimulates fracture healing when administered to mice and rats[1].
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