ZLJ-6
CAS No. : 1051931-39-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $86 | Get quote |
| 5mg | $378 | Get quote |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-113807 |
| M.Wt: | 375.42 |
| Formula: | C13H17N3O6S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ZLJ-6 is a dual COX and 5-LOX inhibitor with oral activity. The IC50 values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity[1][1].
In Vitro:ZLJ-6 (3, 10, 30 μM, 6 h) can effectively inhibit the expression of TNF-α-induced monocyte endothelial interaction and adhesion molecules (e-selectin, ICAM-1 and VCAM-1)[1].
In Vivo:ZLJ-6 (3, 10, 30 mg/kg, oral) shows effective anti-inflammatory activity in carrageenan-induced rat plantar edema model, and analgesic activity in acetic acid-induced mouse peritoneal construction model[2].
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