SPI-112
CAS No. : 1051387-90-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $35 | In-stock |
| 10mg | $55 | In-stock |
| 25mg | $110 | In-stock |
| 50mg | $198 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-101964 |
| M.Wt: | 468.46 |
| Formula: | C22H17FN4O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively[1][2].
IC50 & Target:IC50: 1 μM (SHP2), 18.3 μM (PTP) and 14.5 μM (PTP1B)[2]
In Vitro: SPI-112 has a polar -NO2 or a negatively charged -COOH group and has no detectable cellular activity, suggesting that SPI-112 is not cell permeable[1].
In surface plasmon resonance (SPR) binding assay, SPI-112 displays a 1:1 stoichiometric binding kinetics to SHP2 with a kinetic constant KD of 1.30 µM. Enzyme kinetic data obtained with SPI-112 are best fitted with the competitive inhibition model (Ki of 0.8 µM), suggesting that SPI-112 interacts with the catalytic site of SHP2[1].
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