Ro-51
CAS No. : 1050670-85-3
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| Cat. No. : | HY-14485 |
| M.Wt: | 474.29 |
| Formula: | C17H23IN4O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ro-51 is a potent and selective dual P2X3/P2X2/3 antagonist, with IC50 of 2 nM and 5 nM for P2X3 and P2X2/3, respectively. Ro-51 can be used for the research for pain[1][2].
IC50 & Target: IC50: 2 nM (P2X3), 5 nM (P2X2/3)[1]
In Vitro: Ro-51 has highly selective for P2X 3 and P2X 2/3 exhibiting no antagonistic activity at other P2X receptor family members tested (P2X 1 , P2X 2 , P2X 4 , P2X 5 , and P2X 7 ) at concentrations up to 10 μM[1].
RO51 also shows a significant drop in potency on human P2X3 receptors (IC50 = 110.5 and 0.04 nM, respectively for human and rat P2X3)[2].
In Vivo: Ro-51 suffers rapid clearance, short half-lives, and high protein binding in rat[1].
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