Naspm (trihydrochloride)
CAS No. : 1049731-36-3
(Synonyms: 1-Naphthylacetyl spermine trihydrochloride)
| Size | Price | Stock |
|---|---|---|
| 5mg | $106 | In-stock |
| 10mg | $143 | In-stock |
| 50mg | $506 | In-stock |
| 100mg | $891 | In-stock |
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| Cat. No. : | HY-12506A |
| M.Wt: | 479.91 |
| Formula: | C22H37Cl3N4O |
| Purity: | >98 % |
| Solubility: | H2O : 50 mg/mL (ultrasonic);DMSO : 6.4 mg/mL (ultrasonic) |
Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. In Vitro: NASPM selectively suppresses the inwardly rectifying and Ca2+-permeable AMPA receptors expressed in type II neurons. It has no effect on AMPA receptors in type I neurons. At -60 mV, NASPM suppresses AMPA receptors in type II neurons with an IC50 value of 0.33 µM. The blocking effect of NASPM on the Ca2+-permeable AMPA receptors is use and voltage-dependent[1].
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