NF023 (hexasodium)
CAS No. : 104869-31-0
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| 5mg | $600 | In-stock |
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| Cat. No. : | HY-108676 |
| M.Wt: | 1162.88 |
| Formula: | C35H20N4Na6O21S6 |
| Purity: | >98 % |
| Solubility: | H2O : ≥ 116.3 mg/mL |
NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively[1][2][3][4].
In Vitro: NF023 is selective for recombinant Gi alpha-1 and recombinant Go alpha (EC50 value of approximately 300 nM)[2].
NF023 inhibits P2X1 receptors in a voltage-insensitive manner. NF023 (5 and 30 μM) causes a shift of the concentration-response curve to the right without affecting the maximal response to ATP (KB=1.190.2 μM)[4].
In Vivo: NF023 (100 μmol/kg i.v.) antagonizes vasopressor responses to α,β-mATP but not to noradrenaline In pithed rats[3].
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