Methoctramine (tetrahydrochloride)
CAS No. : 104807-46-7
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| Cat. No. : | HY-116294A |
| M.Wt: | 728.75 |
| Formula: | C36H66Cl4N4O2 |
| Purity: | >98 % |
| Solubility: | H2O : 20 mg/mL (ultrasonic) |
Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine tetrahydrochloride can inhibit Muscarine (HY-121404)-induced bradycardia in vivo. Methoctramine tetrahydrochloride can be used in the study of cardiovascular diseases[1][2][3].
IC50 & Target:M2 muscarinic receptor[1]
In Vitro:Methoctramine tetrahydrochloride attenuates Acetylcholine (ACh)- and Arecaidine propargyl ester (APE)-induced increases in PG synthesis in a concentration-dependent manner[1].
Methoctramine (0.01-1 μM) tetrahydrochloride causes facilitation of contractions induced by both pre- and postganglionic nerve stimulation in the guinea-pig isolated, innervated tracheal tube preparation[2].
Methoctramine (≥10 μM) tetrahydrochloride reduces responses to both nerve stimulation and exogenous ACh[2].
In Vivo:Methoctramine (300 μg/kg; i.v.) tetrahydrochloride strongly inhibits the Methacholine- and Muscarine-induced bradycardia in the anaesthetized rat, respectively[3].
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