MALT1 inhibitor MI-2
CAS No. : 1047953-91-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $121 | In-stock |
| 10mg | $160 | In-stock |
| 50mg | $400 | In-stock |
| 100mg | $650 | In-stock |
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| Cat. No. : | HY-12276 |
| M.Wt: | 455.72 |
| Formula: | C19H17Cl3N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 46 mg/mL |
MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC50=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals[1].
IC50 & Target: IC50: 5.84 μM (MALT1)[1]
In Vitro: MALT1 inhibitor MI-2 (1-1000 nM; 48 hours) selectively suppresses MALT1-dependent DLBCL cell lines, and the GI50 in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells is 0.2, 0.5, 0.4, and 0.4 µM, respectively[1].
MALT1 inhibitor MI-2 (62-1000 nM; 24 hours) causes a dose-dependent decrease in MALT1-mediated cleavage[1].
In Vivo: MALT1 inhibitor MI-2 (25 mg/kg; i.p.; daily for 14 days) profoundly suppresses the growth of both the TMD8 and HBL-1 ABC-DLBCL xenografts[1].
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