Uprosertib hydrochloride
CAS No. : 1047635-80-2
(Synonyms: GSK2141795 (hydrochloride))
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| Cat. No. : | HY-15965A |
| M.Wt: | 465.71 |
| Formula: | C18H17Cl3F2N4O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively. IC50 & Target: IC50: 180 nM (Akt1), 328 nM (Akt2), 38 nM (Akt3) In Vitro: Uprosertib inhibits Akt1/2/3 with the Kd values of 16/49/5 nM, respectively. Uprosertib potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts. Protein targets that bind Uprosertib in the lysate show a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug show no reduction in binding[1].
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