Barnidipine
CAS No. : 104713-75-9
(Synonyms: Mepirodipine; YM-09730-5 (Free base))
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| Cat. No. : | HY-107322A |
| M.Wt: | 491.54 |
| Formula: | C27H29N3O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Barnidipine (Mepirodipine) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki = 0.21 nmol/L), has selective action against CaA receptors. Barnidipine is an orally effective antihypertensive agent that can reduce the level of platelet-derived growth factor B-chain mRNA and peripheral vascular resistance[1][2][3].
IC50 & Target:Ki: 0.21 nmol/l ([3H] initrendipine)[1]
In Vivo:Salt form dose:
Barnidipine hydrochloride (53 mg/kg; Feed administration; 3 weeks) reduces the level of platelet-derived growth factor B chain mRNA in spontaneously hypertensive rats, and has a effect on lowering blood pressure[3].
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