Dexpramipexole (dihydrochloride) (Standard)
CAS No. : 104632-27-1
(Synonyms: (R)-Pramipexole (dihydrochloride) (Standard); R-(+)-Pramipexole (dihydrochloride) (Standard); KNS-760704 (dihydrochloride) (Standard))
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| Cat. No. : | HY-17355AR |
| M.Wt: | 284.25 |
| Formula: | C10H19Cl2N3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Dexpramipexole ((R)-Pramipexole) dihydrochloride (Standard) is the analytical standard of Dexpramipexole (dihydrochloride). This product is intended for research and analytical applications. Dexpramipexole dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.
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