Menthone

Menthone, an orally active monoterpene that can be isolated from plants and Mentha oil with antibacterial, antitumor, antioxidation, and antivirus properties. Menthone is a main volatile component of the essential oil, and has anti-Inflammatory properties in Schistosoma mansoni infection and rheumatoid arthritis^[1][2]. In Vitro:Menthone (0.05-500 μM, 48 h) has optimal concentration for murine primary lung mast cells viability are 0.5, 5 and 50 μM^[3].
Menthone (0.5-50 μM, 48 h) inhibits the secretion of proinflammatory cytokine TNF-α and have anti-inflammatory potential to LPS-stimulated lung mast cells^[3].
Menthone (100 μM, 24 h) inhibits activation of the key transcription factor STAT1 of IFN-I signaling and promotes Tyk2 polyubiquitination to reduce Tyk2 protein levels in 2fTGH cells^[4].
In Vivo:Menthone (100 mg/kg, Articulus injection, 14 days) inhibits the expression of Th1 and Th17 cells in CIA mouse model^[1].
Menthone (8-200 mg/kg, i.g. , daily, 5 weeks) improves the allergic inflammatory statu of the lungs and airways in OVA-sensitized and challenged allergic asthmatic inflammation mouse model by modulating the Th2-biased immune balance and mitigating mast cell degranulation^[3].
Menthone (100 mg/kg, Articulus injection, 14 days) contributes to the relief of local inflammation of rheumatoid arthritis in CIA mice^[1][4].