Nitromifene
CAS No. : 10448-84-7
(Synonyms: CI-628)
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| Cat. No. : | HY-100266 |
| M.Wt: | 444.52 |
| Formula: | C27H28N2O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Nitromifene is an antagonist of estrogen receptor (ER). IC50 & Target:ER[1] In Vitro: Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase[1].
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