Sabeluzole
CAS No. : 104383-17-7
(Synonyms: R 58735)
| Size | Price | Stock |
|---|---|---|
| 5mg | $155 | In-stock |
| 10mg | $250 | In-stock |
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| Cat. No. : | HY-105022 |
| M.Wt: | 415.52 |
| Formula: | C22H26FN3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Sabeluzole (R 58735), a benzothiazol derivative, has antiischemic, antiepileptic, and cognitive-enhancing properties. Sabeluzole protects rat hippocampal neurons against NMDA- and glutamate-induced neurotoxicity via preventing tau expression. Sabeluzole enhances memory in rats, and prevents the amnesic effect of Chlordiazepoxide. Sabeluzole can be used fro research of Alzheimer's disease[1][2].
In Vitro:Sabeluzole (50 nM, 100 nM; 20 min before cell injury) exhibits protection in glutamate (50 μM)-mediated excitotoxicity in primary culture of cerebellar granule cell[1].
Sabeluzole (50 nM; 7 d) inhibits tau protein level increase induced by glutamate[1].
Sabeluzole (50 nM; 4 d) shows neuroprotective effects in human neuroblastoma cell line SH-SY5Y[1].
In Vivo:Sabeluzole (5 mg/kg, 25 mg/kg; sc; twice dose with 72 h interval) shows positive and memory enhancing properties in habituation amnesia male rats induced with 20 mg/kg Chlordiazepoxide[2].
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