Leminoprazole
CAS No. : 104340-86-5
(Synonyms: NC 1300O3)
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| Cat. No. : | HY-105094 |
| M.Wt: | 341.47 |
| Formula: | C19H23N3OS |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Leminoprazole (NC 1300O3) is an inhibitor for acid pump, H+ K+-ATPase,. Leminoprazole stimulates the secretion and synthesis of gastric mucus, attenuates gastric ulcers. Leminoprazole is orally active[1][2][3].
In Vitro:Leminoprazole inhibits H+,K+-ATPase in rabbit gastric vesicle irreversibly through formation of covalent disulfide bond, with IC50 of 5.3 and 19 μM[1].
Leminoprazole inhibits histamine, carbachol, gastrin and db-cAMP-stimulated acid secretion, with IC50s of 0.4, 0.35, 0.25 and 0.56 μM, respectively[2].
In Vivo:Leminoprazole (10-90 mg/kg, po, single dose) promotes the synthesis of gastric mucus, inhibits gastric acid secretion in Donryu rats model[3].
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