ABC1183
CAS No. : 1042735-18-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $104 | In-stock |
| 25mg | $200 | In-stock |
| 50mg | $330 | In-stock |
| 100mg | $540 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100950 |
| M.Wt: | 334.39 |
| Formula: | C18H14N4OS |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
ABC1183 is an orally active selective dual GSK3 and CDK9 inhibitor. ABC1183 inhibits GSK3β, GSK3α and CDK9/cyclin T1 with the IC50 values of 657 nM, 327 nM and 321 nM, respectively. ABC1183 has anti-inflammatory and anti-tumor activities[1].
In Vitro: ABC1183 (3 μM, 24 h) can block cell cycle progression and thus affect cell proliferation[1].
In Vivo: ABC1183 (oral gavage, 5 or 50 mg/kg) inhibits tumor proliferation through negative regulation of cell growth and pro-inflammatory signalling in male C57BL/6 mice[1].
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