AZD7507
CAS No. : 1041852-85-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $180 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $600 | In-stock |
| 50mg | $900 | In-stock |
| 100mg | $1350 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-117244 |
| M.Wt: | 454.50 |
| Formula: | C23H27FN6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 130 mg/mL (ultrasonic) |
AZD7507 is a potent and orally active CSF-1R inhibitor, with antitumor activity. IC50 & Target: CSF-1R[1] In Vitro: AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC50, 32 nM), shows inhibitory activity against hERG and NaV1.5, with IC50s of >30 and 26 μM[1]. In Vivo: AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC50 is >20 μM[1]. AZD7507 significantly decreases the number of CD68+ macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells[2].
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- AZD7507
- Cat. No.:
- HY-117244
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