Eicosapentaenoic Acid
CAS No. : 10417-94-4
(Synonyms: EPA; Timnodonic acid)
| Size | Price | Stock |
|---|---|---|
| 50mg | $66 | In-stock |
| 100mg | $84 | In-stock |
| 500mg | $336 | In-stock |
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| Cat. No. : | HY-B0660 |
| M.Wt: | 302.45 |
| Formula: | C20H30O2 |
| Purity: | >98 % |
| Solubility: | Ethanol : ≥ 100 mg/mL;DMSO : ≥ 30 mg/mL |
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].
In Vitro: C/EBPβ phosphorylated form is evident in Eicosapentaenoic Acid (EPA; 100 µM; 24 h) treated cells, whereas it was barely detectable in control, and OA or LA treated U937[1].
Eicosapentaenoic Acid (100 µM; 1, 3, 24 h) causes a significant increase of H-Ras and N-Ras mRNA levels conditioning for 1 and 3 hours. K-Ras mRNA levels were not affected by Eicosapentaenoic Acid[1].
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