AMG-8562
CAS No. : 1041478-78-7
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| Cat. No. : | HY-114583 |
| M.Wt: | 430.47 |
| Formula: | C24H25F3N2O2 |
| Purity: | >98 % |
| Solubility: |
AMG-8562 is a TRPV1 modulator. AMG-8562 blocks Capsaicin (HY-10448) activation of TRPV1 without affecting heat activation of TRPV1. AMG-8562 potentiates pH 5 activation of TRPV1. AMG-8562 blocks capsaicin-induced flinching behavior in pain models. AMG-8562 produces significant efficacy in CFA- and skin incision-induced thermal hyperalgesia, and in the Acetic acid (HY-Y0319)-induced writhing models[1].
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