STAT3-IN-5
CAS No. : 1041438-68-9
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| Cat. No. : | HY-112447 |
| M.Wt: | 444.26 |
| Formula: | C19H7F7N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
STAT3-IN-5 is a potent STAT3 inhibitor. STAT3-IN-5 inhibits STAT3-Y705 phosphorylation with an EC50 value of 170 nM. STAT3-IN-5 inhibits cytokine induced JAK activation. STAT3-IN-5 induces apoptosis. STAT3-IN-5 can be used in research of cancer[1].
In Vitro:STAT3-IN-5 (compound 8; 0-2 μM; 1 h) inhibits STAT3 phosphorylation in U266 cells[1].
STAT3-IN-5 (0-2 μM; 1 h) inhibits cytokines induced phosphorylation of JAK1, JAK2, and Tyk2 in U266 cells[1].
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