Anethole

Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer^{[1][2][3][4][5]}. In Vitro: Anethole (0.5-1 μM; 1 h) can inhibit H2O2 (300 Μm; 24 h)-induced apoptosis and viability loss in human skin fibroblasts CRL1474^[2].
Anethole has synergistic effects on the antifungal activities of phytochemicals including polygodial and 2E-undecenal against Saccharomyces cerevisiae and Candida albicans^[3].
In Vivo: Anethole (62.5-500 mg/kg; Intraperitoneal injection, single dose) has an anti-inflammatory effect in BALB/C mice induced by LPS (1.5 mg/kg) (HY-D1056)^[4].
Anethole (250-1000 mg/kg; P.O.; Once every other day for 60 consecutive days) has anti-tumor effects in Ehrlich ascites tumor Swiss albino mice^[5].