Thiacetazone
CAS No. : 104-06-3
(Synonyms: Thioacetazone; Amithiozone)
| Size | Price | Stock |
|---|---|---|
| 100mg | $30 | In-stock |
| 200mg | $54 | In-stock |
| 500mg | $119 | In-stock |
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| Cat. No. : | HY-B1526 |
| M.Wt: | 236.29 |
| Formula: | C10H12N4OS |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Thiacetazone (Thioacetazone) is a thiourea-containing antitubercular agent and is an orally active antibiotic. Thiacetazone has antibacterial action, which inhibits growth of Mycobacterium tuberculosis H37Rv with a MIC value of 0.1 μg/mL[1]. IC50 & Target: MIC: 0.1 μg/mL (Mycobacterium tuberculosis H37Rv)[1] In Vitro: Thiacetazone is a prodrug that is activated by the mycobacterial monooxygenase EthA, which is also the activator of two other anti-tuberculosis agents, Ethionamide and Isoxyl[3]. In Vivo: The Km and Vmax values for the N-deacetylation of Thiacetazone are 0.57 mM and 0.123 nmol of p-aminobenzaldehydethiosemicarbazone formed/min/mg cytosolic protein, respectively. The ability to metabolize Thiacetazone is the same in the livers of cat, mouse and human, but lagged significantly in that of rat[2].
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