Nodosin

Nodosin is an orally active diterpenoid compound that can be isolated from Isodon serra. Nodosin can inhibit the proliferation and induce cell cycle arrest and apoptosis of tumor cells. Nodosin can also inhibit oxidative stress, inflammatory responses, and ferroptosis. Nodosin has anti-inflammatory and anti-tumor activities^[1][2][3]. In Vitro:Nodosin (0-30 μM; 18-72 h) can inhibit the growth of multiple tumor cell lines (the IC₅₀ values for SNU638, SK-HEP-1, A549, HCT116, and MDA-MB-231 are 7.53, 5.33, 13.73, 4.05, and 7.12 μM, respectively), and induce cell cycle arrest and apoptosis in HCT116 cells. The mechanism involves the inhibition of the Wnt/β-catenin signaling pathway^[1]. In Vivo:Nodosin (2-4 mg/kg; oral administration; 7 days) has an ameliorating effect in a rat model of acute kidney injury^[2].
Nodosin (100 μg/mL; tail vein injection; single dose) has a protective effect in a rat liver transplantation model. It can reduce the pathological damage of rat liver tissue, decrease the number of apoptotic hepatocytes, and promote hepatocyte proliferation^[3].