Tulrampator
CAS No. : 1038984-31-4
(Synonyms: CX-1632; S-47445)
| Size | Price | Stock |
|---|---|---|
| 5mg | $54 | In-stock |
| 10mg | $88 | In-stock |
| 25mg | $166 | In-stock |
| 50mg | $265 | In-stock |
| 100mg | $425 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-109046 |
| M.Wt: | 380.37 |
| Formula: | C20H17FN4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C) |
Tulrampator (S-47445) is an orally active selective AMPA receptor modulator. Tulrampator possesses procognitive, enhancing synaptic plasticity, anti-depressant-anxiolytic-like, procognitive and potential neuroprotective properties. Tulrampator can be used for research of alzheimer’s disease and in major depressive disorder[1][2][3].
IC50 & Target:AMPAR[1]
In Vitro:Tulrampator (0.1 μM, 2 days) markedly enhances the amplitude of the glutamate-evoked current and prolongs the response in HEK-293 cells[1].
Tulrampator (0.1-10 μM, 24 h) shows absence of toxicity on rat primary cortical cells[1].
In Vivo:Tulrampator (0.3-10 mg/kg, Oral gavage, once a day for 4-5 weeks) has anxiolytic-like and antidepressant-like effects in the CORT Mice Model[2].
Tulrampator (1-10 mg/kg, Intraperitoneal injection, once a day for 4 weeks) reverts olfactory bulbectomy (OB)-induced hyperactivity and anxiety in bilateral olfactory bulbectomy mice model[3].
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