Lacidipine
CAS No. : 103890-78-4
| Size | Price | Stock |
|---|---|---|
| 10mg | $25 | In-stock |
| 25mg | $42 | In-stock |
| 50mg | $67 | In-stock |
| 100mg | $108 | In-stock |
| 250mg | $218 | In-stock |
| 500mg | $350 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-B0347 |
| M.Wt: | 455.54 |
| Formula: | C26H33NO6 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Lacidipine is an orally active and highly selective L-type calcium channel blocker that acts on smooth muscle calcium channels, primarily dilates peripheral arteries, reduces peripheral resistance, and has long-lasting anti-hypertensive activity. Lacidipine protects HKCs from apoptosis induced by ATP depletion and recovery by modulating the caspase-3 pathway. Lacidipine can be used in studies of hypertension, atherosclerosis and acute kidney injury (AKI)[1][2].
In Vitro: Lacidipine (0.01-100 μM; 24 h) inhibits HKCs proliferation in vitro in a concentration-dependent manner[1].
Lacidipine (0.01-100 μM; 24 h) protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway[1].
In Vivo: Lacidipine (0.3, 1.0, 3.0 mg/kg; p.o.; single daily for 10 weeks) shows anti-atherogenic effects in the apoE-deficient mouse, and reduces plasma endothelin concentrations[2].
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