Pyrazine diazohydroxide (sodium)
CAS No. : 103829-46-5
(Synonyms: NSC-361456 (sodium))
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| Cat. No. : | HY-19045 |
| M.Wt: | 147.09 |
| Formula: | C4H4N4NaO |
| Purity: | >98 % |
| Solubility: |
Pyrazine diazohydroxide (NSC 361456) sodium is an anti-tumor agent that forms DNA adducts via the reactive pyrazine diazonium ion. Pyrazine diazohydroxide sodium can be used for the study of renal cancer, colorectal cancer, melanoma and leukemia[1][2]. In Vivo:Pyrazine diazohydroxide (sodium) (44.5-150 mg/kg, i.p., once each on Day 12, 16, and 20) shows significantly higher tumor cell killing effect on lung metastases in LOX melanoma ascites cells xenograft mice compared to primary tumors[1].
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