R916562
CAS No. : 1037798-41-6
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| Cat. No. : | HY-104075 |
| M.Wt: | 536.09 |
| Formula: | C26H30ClN9S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis[1]. In Vivo: R916562 treatment at 85 mg/kg or 125 mg/kg orally b.i. d for 21 days results in statistically significant tumor growth inhibitions of 69% or 83% respectively. R916562 shows 73% reduction in fibroblast growth factor-induced neovascularization in a mouse corneal micropocket assay at a dose of 100 mg/kg and 50% reduction at 50 mg/kg[1].
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