Gimeracil
CAS No. : 103766-25-2
(Synonyms: Gimestat)
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| Cat. No. : | HY-17469 |
| M.Wt: | 145.54 |
| Formula: | C5H4ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD)[1][2].
In Vitro: Gimeracil reduces the frequency of neo-positive clones. Additionally, it sensitized the cells in S-phase more than in G0/G1[1].
Gimeracil may enhance the efficacy of radiotherapy through the suppression of HR-mediated DNA repair pathways[1].
Gimeracil pretreatment significantly restrains the formation of radiation-induced foci of Rad51 and RPA, whereas it increased the number of foci of Nbs1, Mre11, Rad50, and FancD2[2].
In Vivo: Gimeracil (2.5-25 mg/kg, orally) may inhibit the rapid repair of X-ray-induced DNA damage in tumors[3].
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