Sulfadimethoxine (sodium)

Sulfadimethoxine (Sulphadimethoxine) sodium is an orally active sulfonamide antibiotic. Sulfadimethoxine sodium reduces Eimeria-related mortality, weight loss, and lesions. Sulfadimethoxine sodium can be used for the research of avian coccidiosis^[1]. IC50 & Target:Antibacterial^[1] In Vitro:Sulfadimethoxine (50 µg/mL; 24 h) sodium exhibits extensive (87.5%) binding to plasma proteins from domestic short-haired cats when tested via equilibrium dialysis at 37°C^[3]. In Vivo:Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) sodium administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria tenella-infected chicks, with 0.05% supporting the highest weight gain^[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) sodium administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria necatrix-infected chicks, while 0.025% is ineffective against this species^[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) sodium administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria acervulina-infected chicks, with 0.05% supporting weight gain equal to uninfected controls^[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) sodium administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria maxima-infected chicks, with all doses supporting similar weight gain^[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) sodium administered in drinking water starting 3 days post-infection provides complete mortality protection and eliminates pathological lesions in Eimeria brunetti-infected chicks^[1].
Sulfadimethoxine (0.025-0.1%; p.o.; daily; 6 days) sodium administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria mivati-infected chicks, with 0.05% supporting weight gain greater than uninfected controls^[1].
Sulfadimethoxine (0.05%; p.o.; daily; 6 days) sodium administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in chicks with mixed Eimeria infections^[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) sodium administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria gallopavonis-infected turkey poults, with 0.025% supporting weight gain greater than uninfected controls^[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) sodium administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria meleagrimitis-infected turkey poults^[1].
Sulfadimethoxine (0.0125-0.05%; p.o.; daily; 6 days) sodium administered in drinking water starting 3 days post-infection provides complete mortality protection and reduces pathological lesions in Eimeria adenoeides-infected turkey poults^[1].