PIM-IN-4
CAS No. : 1036380-87-6
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| Cat. No. : | HY-18088 |
| M.Wt: | 351.42 |
| Formula: | C19H17N3O2S |
| Purity: | >98 % |
| Solubility: |
PIM-IN-4 is a Pim kinase inhibitor with Ki values of 2, 3, and 0.5 nM against Pim-1, 2, 3, respectively. PIM-IN-4 blocks the phosphorylation of the pro-apoptotic protein Bad. PIM-IN-4 inhibits the growth of leukemia cells. PIM-IN-4 is applicable for leukemia-related research[1].
In Vitro:PIM-IN-4 (Compound 14j) (0.01-30 μM; 48 h) inhibits the proliferation of K562 and MV4-11 human leukemia cells with EC50 values of 1.7 μM and 2.4 μM, respectively[1].
PIM-IN-4 (4 h) inhibits Bad serine-112 phosphorylation in K562 human leukemia cells with an EC50 value of 0.5 μM[1].
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