Lansoprazole
CAS No. : 103577-45-3
(Synonyms: AG-1749)
| Size | Price | Stock |
|---|---|---|
| 500mg | $55 | In-stock |
| 1g | $79 | In-stock |
| 5g | $343 | In-stock |
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| Cat. No. : | HY-13662 |
| M.Wt: | 369.36 |
| Formula: | C16H14F3N3O2S |
| Purity: | >98 % |
| Solubility: | H2O : < 0.1 mg/mL;DMSO : ≥ 100 mg/mL;Ethanol : 10 mg/mL (ultrasonic) |
Lansoprazole (AG 1749) is an orally active proton pump inhibitor which prevents the stomach from producing acid. Lansoprazole (AG 1749) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[1][2].
In Vitro: Lansoprazole from 0.3 to 3 μM inhibits gastric acid formation in a concentration-dependent manner (IC50 of 0.76 μM)[4].
Lansoprazole (30-300 μM) both induced concentration-dependent, reversible and reproducible relaxations of arteries[5].
In Vivo: Lansoprazole (20-40 mg/kg) treatment significantly attenuated STZ and HFD -induced memory deficits, biochemical and histopathological alterations[3].
Lansoprazole (20 mg/kg and 40 mg/kg, p.o.) significantly reduces the STZ and HFD- induced increase in AChE activity[3].
Lansoprazole (20 mg/kg and 40 mg/kg, p.o.) significantly reduces the STZ and HFD- induced rise in brain MPO level[3].
Further HFD mice treated with lansoprazole (20 mg/kg and 40 mg/kg, p.o.) shows a marked decrease in the body weight in comparison to the control animals[3].
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