Sarecycline

Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne^{[1][2][3][4][5][6]}. In Vitro:Sarecycline inhibits 55 clinical isolates of C. acnes, and the MIC values for Sarecycline ranged from 0.5 to 16  µg/ml; the MIC50 was 0.5 µg/ml, and the MIC90 was 4 µg/ml^[1].
Sarecycline exhibits activity against the macrolide-resistant organisms^[1].
Sarecycline hydrochloride exhibits minimal activity against enteric aerobic Gram-negative bacteria^[2].
In Vivo:Sarecycline hydrochloride (0.33-9  mg/kg; i.v.) show potent activity against S. aureus in a murine neutropenic thigh infection model^[1].
Sarecycline can inhibit S. aureus (PD₅₀=0.25 mg/kg), but has no significant effect on E. coli even at the highest dose (>40 mg/kg) in CD-1 mice model of systemic (intraperitoneal) infection^[6].
Sarecycline (1-150mg/kg; Intraperitoneal injection; Single dose) shows anti-inflammatory activity in Sprague Dawley rats model^[6].