ML162
CAS No. : 1035072-16-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $145 | In-stock |
| 25mg | $290 | In-stock |
| 50mg | $450 | In-stock |
| 100mg | $630 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100002 |
| M.Wt: | 477.40 |
| Formula: | C23H22Cl2N2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (209.47 mM; Need ultrasonic) |
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. ML162 has a selective lethal effect on mutant RAS oncogene-expressing cell lines[1][2]
In Vitro: ML162 (compound 1a) shows nanomolar potencies against two HRASG12V expressing cell lines, with IC50 values of 25 nM and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively[1].
ML162 (8 μM; 24 hours) treatment increases the expression of p62 and Nrf2 in chemoresistant HN3R and HN3-rslR cells, inactivates Keap1, and increases expression of the phospho-PERK-ATF4-SESN2 pathway[2].
ML162 induces the head and neck cancer (HNC) cell death to varying degrees, with parental HN3 cells more sensitive and cisplatin-resistant (HN3R) and acquired RSL3-resistant (HN3-rslR) cells less sensitive[2].
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