Leupeptin (hemisulfate)
CAS No. : 103476-89-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $84 | In-stock |
| 25mg | $176 | In-stock |
| 50mg | $285 | In-stock |
| 100mg | $452 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-18234A |
| M.Wt: | 475.59 |
| Formula: | C20H38N6O4.1/2H2SO4 |
| Purity: | >98 % |
| Solubility: | H2O : 83.33 mg/mL (ultrasonic;warming;heat to 60°C) |
Leupeptin hemisulfate is a broad-spectrum, membrane-permeable protease inhibitor. Leupeptin hemisulfate potently inhibits serine, cysteine and threonine proteases. Leupeptin hemisulfate inhibits Mpro (the main protease of SARS-CoV-2) and also has anti-inflammatory activity[1][2][3].
IC50 & Target:Cathepsin B, Cathepsin H, Cathepsin L, Ser/Thr Protease, Mpro[1][2][3].
In Vitro:Leupeptin hemisulfate (0.06-200 µM; 72 h) significantly decreases copy numbers of SARS-CoV-2 viral RNA (vRNA) in Vero cells[1]
Leupeptin hemisulfate inhibits RNA levels of SARS-CoV-2 in Vero cells, with an EC50 value of 42.34 µM[1].
Leupeptin hemisulfate has some inhibitory activity against Mpro, with an IC50 value of 127.2 µM[1].
Leupeptin hemisulfate againsts human coronavirus strain 229E with an IC50 value of 0.4 µg/mL (about 1 µM)[1].
In Vivo:Leupeptin hemisulfate (0, 9, 18, 36 mg/kg; i.p.; single) is well tolerated by the animals and produces a strong, dose-dependent increase in LC3b-II in both the total tissue extracts and the lysosome and autophagosome-enriched pellet fraction[2].
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