Maprotiline (hydrochloride)
CAS No. : 10347-81-6
| Size | Price | Stock |
|---|---|---|
| 100mg | $66 | In-stock |
| 500mg | $132 | In-stock |
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| 5 g | Get quote | |
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| Cat. No. : | HY-B0444 |
| M.Wt: | 313.86 |
| Formula: | C20H24ClN |
| Purity: | >98 % |
| Solubility: | H2O : 2.2 mg/mL (ultrasonic);DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C) |
Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1[1][2].
In Vitro:Maprotiline (0-20 μM, 0-72 h) hydrochloride inhibits the growth of Huh7 and HepG2 cells and induces cell apoptosis[1].
Maprotiline (0-20 μM, 0-72 h) hydrochloride inhibits the metastasis of liver cancer cells[1].
Maprotiline (0-20 μM, 72 h) hydrochloride affects the ERK pathway and inhibits the phosphorylation of SREBP2 in HepG2 and Huh7 cells[1].
Maprotiline hydrochloride targets CRABP1 and regulates cholesterol biosynthesis in HCC cells[1].
In Vivo:Maprotiline (20-40 mg/kg, intraperitoneal injection, twice a week for three weeks) hydrochloride inhibits liver cancer tumor growth in mice[1].
Maprotiline (3-30 mg/kg, intravenous injection, single dose) hydrochloride combined with the synthetic cannabinoid WIN 55,212-2 effectively reduces neuropathic pain in mice[2].
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