CTOP
CAS No. : 103429-31-8
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|---|---|---|
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| Cat. No. : | HY-P1329 |
| M.Wt: | 1062.26 |
| Formula: | C50H67N11O11S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CTOP is a potent and highly selective μ-opioid receptor antagonist. CTOP antagonizes the acute morphine-induced analgesic effect and hypermotility. CTOP enhances extracellular dopamine levels in the nucleus accumbens. CTOP dose-dependently enhances locomotor activity[1][2].
In Vivo: CTOP (0-0.5 nmol, ICV, once) antagonizes the analgesic effect of morphine in a dose-dependent manner[1].
CTOP (0-2 nmol, ICV, once) causes withdrawal hypothermia and a loss of body weight in morphine-dependent animals[1].
CTOP (0-1.5 nmol per side, Intra-VTA injection) enhances extracellular dopamine levels in the nucleus accumbens and dose-dependently enhances locomotor activity[2].
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