Monatepil (maleate)
CAS No. : 103379-03-9
(Synonyms: AJ-2615)
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| Cat. No. : | HY-106818A |
| M.Wt: | 591.69 |
| Formula: | C32H34FN3O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Monatepil maleate (AJ-2615) is a potent and orally active Ca2+-channel antagonist and a noncompetitive ACAT inhibitor. Monatepil maleate decreases blood pressure and improves plasma lipid metabolism. Monatepil maleate has the potential for the research of hyperlipidemia[1][2].
In Vivo:Monatepil maleate (30 mg/kg; p.o.; once daily for 9 weeks) improves plasma lipid metabolism[1].
Monatepil maleate (30 mg/kg; p.o.; once daily for 6 weeks) inhibits ACAT activity and esterifies cholesterol content in high cholesterol diet monkeys[2].
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