GNE-490
CAS No. : 1033739-92-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $160 | In-stock |
| 5mg | $420 | In-stock |
| 10mg | $680 | In-stock |
| 25mg | $1350 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-10812 |
| M.Wt: | 386.47 |
| Formula: | C18H22N6O2S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
GNE-490, a (thienopyrimidin-2-yl)aminopyrimidine, is a potent pan-PI3K inhibitor with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50=750 nM). GNE-490 shows potent suppression efficacy profile against MCF7.1 breast cancer xenograft model[1].
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